Even though he's talking about radio so much of what he's saying relates directly to being an artist/creative professional in general. I love Ira Glass. I really like the reality check he puts on how much of your work is going to be good - they throw out half the stuff they do in a given week. Which makes me feel better, I always feel like I have to be Wonder Woman and create something amazing every time I draw, but sometimes stuff just bombs and you have to kill it.
Oh and I have a total geek girl crush on Ira also so that doesn't hurt haha.